Michigan State University
Pharmacology & Toxicology
Making a
difference.
It's in our DNA.
Hui Xu, MD PhD

Hui Xu, MD PhD

Associate Professor
Pharmacology & Toxicology
(517) 353-6609
B328 Life Sciences

Bio

1. Focus on the autonomic nervous system, molecular signaling and receptor/ion channel interactions in the vasculature, and how these factors regulate vascular and circulatory function in health and human diseases. 2. Approaches include the integrative studies of evaluation of sympathetic nerve and the vascular smooth muscle cell interactions in whole animals (in rats and mice) in vivo, in pressurized arteries and veins in vitro (including tissues from human subjects), and the function of individual ion channels/receptors at the molecular level. 3. Studies focus on the role of vascular ion (BK, L-type Ca2+, and pannexin-1) channel function in the regulation of vascular function and blood pressure, and the contributions of ion channel dysfunction in cardiovascular and gastrointestinal disorders, including septic shock, salt-sensitive and metabolic disorders associated with hypertension, and gastrointestinal dysmotility. 4. Studies focus on the mechanisms of obesity associated hypertension and sex differences in obesity associated hypertension, organ damage (renal injury) and GI dysmotility. 5. My studies also focused on the enteric nerve system in control of brain-gastrointestinal function and motility in Alzheimer's disease, autism, and metabolic disorders-the role of gut-brain axes. 6. My current study is working on the sensory nerve in control of renal function and its role in the chemotherapy-associated renal injury.

Research

Colleges

Education

  • MD, , Xinjiang Medical University ()
  • PhD, , Kagawa University ()

Education

  • QQQ 1MD, 2, 3Xinjiang Medical University 4 ()
  • QQQ 1PhD, 2, 3Kagawa University 4 ()

Funding

  • Identification of enteric nerve circuits controlling gut motility, NIDDK (2019—2025)
  • Does microbiome composition moderate GI and CNS function in a VPA-induced mouse model of autism? , NIHCHD (2023—2026)
  • Neurohumoral control of veins in hypertension , NHLBI (2008—2015)
  • Neurohumoral control of arteries and veins in obesity-associated hypertension , NHLBI (2015—2021)
  • BK channel function in septic shock , American Heart Association (2011—2014)
  • Purinergic neurotransmission in the gut , NIDDK (2012—2018)
  • Endothelin and superoxide facilitate sympathetic neurotransmission to mesenteric veins in DOCA-salt hypertension , American Heart Association (2003—2005)

Works

Employment

  • ZZ1Associate Professor, ZZ2Michigan State University ZZ3East Lansing ZZ$https://ror.org/05hs6h993 (2025)
  • ZZ1Associate Professor, ZZ2Michigan State University ZZ3East Lansing ZZ$3078 (2016—2025)
  • ZZ1Assistant Professor, ZZ2Michigan State University ZZ3East Lansing ZZ$https://ror.org/05hs6h993 (2005—2016)
  • ZZ1Research Associate, ZZ2Michigan State University ZZ3East Lansing ZZ$https://ror.org/05hs6h993 (2000—2005)