Michigan State University
Pharmacology & Toxicology
Making a
difference.
It's in our DNA.
James Luyendyk, PhD

James Luyendyk, PhD

Professor
Pathobiology & DIagnostic Investigation, Pharmacology & Toxicology
(517) 884-2057
240H Food Safety and Toxicology Building

Research

Colleges

Associations

  • Institute for Integrative Toxicology

Programs

Sections

Works

  • Age-associated increases in PAI-1 silenced with siRNA-lipid nanoparticles reduces thrombosis and prolongs lifespan. Blood (2026)
  • Fibrin and Fibrinolysis in Liver, Kidney, and Lung Transplantation. Arterioscler Thromb Vasc Biol (2026)
  • Role of the Plasminogen Activation System in Liver Injury and Repair: Knowns and Known Unknowns. Arterioscler Thromb Vasc Biol (2026)
  • Tissue transglutaminase drives fibrin β-chain cross-linking: a novel fibrin modification observed in patients with trauma. Blood (2026)
  • Urokinase Plasminogen Activator Deficiency Delays the Development of Obesity and Metabolic Sequelae. Arterioscler Thromb Vasc Biol (2026)
  • Factor XIII: driving (cross-)links in hemostasis, thrombosis, and disease. Blood (2025)
  • Integrated cross-linking by TG2 and FXIII generates hepatoprotective fibrin(ogen) deposits in injured liver. Blood (2025)
  • Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury. Toxicol Sci (2025)
  • Platelets mediate neutrophil infiltration and exacerbate liver injury and sinusoidal endothelial cell damage after a severe acetaminophen overdose in mice. Arch Toxicol (2025)
  • A bovine model of hypoxia-induced pulmonary hypertension reveals a gradient of immune and matrisome response with a complement signature found in circulation. Am J Physiol Cell Physiol (2024)
  • Coagulation factor XIII is a critical driver of liver regeneration after partial hepatectomy. J Thromb Haemost (2024)
  • Fibrinolysis-Mediated Pathways in Acute Liver Injury. Semin Thromb Hemost (2024)
  • Good Cells Go Bad: Immune Dysregulation in the Transition from Acute Liver Injury to Liver Failure After Acetaminophen Overdose. Drug Metab Dispos (2024)
  • Hepatocyte-independent PAR1-biased signaling controls liver pathology in experimental obesity. J Thromb Haemost (2024)
  • Neutrophil-dependent hepatic platelet accumulation and liver injury revealed by acetaminophen dose-response studies. Res Pract Thromb Haemost (2024)
  • Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression. Mol Oncol (2024)
  • Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration. Blood (2024)
  • Altered fibrinogen γ-chain cross-linking in mutant fibrinogen-γ(Δ5) mice drives acute liver injury. J Thromb Haemost (2023)
  • Anticoagulation to prevent disease progression in patients with cirrhosis. J Hepatol (2023)
  • Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36. Nat Cardiovasc Res (2023)
  • Interleukin-10 disrupts liver repair in acetaminophen-induced acute liver failure. Front Immunol (2023)
  • Novel genetic regulators of fibrinogen synthesis identified by an in vitro experimental platform. J Thromb Haemost (2023)
  • Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure. J Thromb Haemost (2023)
  • The ISTH SSC Subcommittee on Hemostatic Management of Patients with Liver Disease: goals, ambitions, and call for collaboration. J Thromb Haemost (2023)
  • The ISTH SSC subcommittee on Hemostatic Management of Patients with Liver Disease: goals, ambitions, and call for collaboration: reply. J Thromb Haemost (2023)
  • Turning clots into stardust: nanoparticles stay on target. J Thromb Haemost (2023)
  • Baat Gene Knockout Alters Post-Natal Development, the Gut Microbiome, and Reveals Unusual Bile Acids in Mice. J Lipid Res (2022)
  • Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells. Mol Pharm (2022)
  • Cross-linking by tissue transglutaminase-2 alters fibrinogen-directed macrophage proinflammatory activity. J Thromb Haemost (2022)
  • Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet-induced obesity and associated pathologies. J Thromb Haemost (2022)
  • Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with an Fga truncation mutation. Blood (2022)
  • Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA. Blood (2022)
  • Editorial of Special Column on Drug- and Chemical-Induced Liver Injury. Acta Pharm Sin B (2021)
  • Factor XIII cross-links fibrin(ogen) independent of fibrin polymerization in experimental acute liver injury. Blood (2021)
  • Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure. Blood (2021)
  • Systemic inflammation and disorders of hemostasis in the AD-ACLF syndrome. J Hepatol (2021)
  • Targeting von Willebrand factor in liver diseases: A novel therapeutic strategy?. J Thromb Haemost (2021)
  • Von Willebrand factor exerts hepatoprotective effects in acute but not chronic cholestatic liver injury in mice. Toxicology (2021)
  • A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice. Blood (2020)
  • Hemostasis and Liver Regeneration. Semin Thromb Hemost (2020)
  • Liver fibrosis is driven by protease-activated receptor-1 expressed by hepatic stellate cells in experimental chronic liver injury. Res Pract Thromb Haemost (2020)
  • Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice. J Hepatol (2020)
  • Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transglutaminase. J Thromb Haemost (2019)
  • Coagulation parameters following equine herpesvirus type 1 infection in horses. Equine Vet J (2019)
  • Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose. Am J Pathol (2019)
  • Direct Amplification of Tissue Factor:Factor VIIa Procoagulant Activity by Bile Acids Drives Intrahepatic Coagulation. Arterioscler Thromb Vasc Biol (2019)
  • Endothelial force awakens a mechanism of portal hypertension: It's a neutrophil extracellular trap!. J Thromb Haemost (2019)
  • Illustrated State-of-the-Art Capsules of the ISTH 2019 Congress in Melbourne, Australia. Res Pract Thromb Haemost (2019)
  • Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans. Blood (2019)
  • The multifaceted role of fibrinogen in tissue injury and inflammation. Blood (2019)
  • Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo. Toxicol Sci (2018)
  • Concepts and Controversies in Haemostasis and Thrombosis Associated with Liver Disease: Proceedings of the 7th International Coagulation in Liver Disease Conference. Thromb Haemost (2018)
  • Plasminogen Activator Inhibitor-1 Reduces Tissue-Type Plasminogen Activator-Dependent Fibrinolysis and Intrahepatic Hemorrhage in Experimental Acetaminophen Overdose. Am J Pathol (2018)
  • Platelets as Modulators of Liver Diseases. Semin Thromb Hemost (2018)
  • Role of the blood coagulation cascade in hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol (2018)
  • Dose-dependent effects of alpha-naphthylisothiocyanate disconnect biliary fibrosis from hepatocellular necrosis. J Biochem Mol Toxicol (2017)
  • Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte α(M)β(2) integrin-dependent upregulation of Mmp12. J Hepatol (2017)
  • Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis. Toxicology (2017)
  • Plasminogen Activator Inhibitor-1 Is Critical in Alcohol-Enhanced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol (2017)
  • Targeting Phospholipase D4 Attenuates Kidney Fibrosis. J Am Soc Nephrol (2017)
  • Thrombin promotes diet-induced obesity through fibrin-driven inflammation. J Clin Invest (2017)
  • Trichloroethylene Exposure Reduces Liver Injury in a Mouse Model of Primary Biliary Cholangitis. Toxicol Sci (2017)
  • Von Willebrand factor deficiency reduces liver fibrosis in mice. Toxicol Appl Pharmacol (2017)
  • Evaluation of the chromogenic anti-factor IIa assay to assess dabigatran exposure in geriatric patients with atrial fibrillation in an outpatient setting. Thromb J (2016)
  • Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism. Blood (2016)
  • From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis. Toxicol Sci (2016)
  • Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury. J Hepatol (2016)
  • Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease. Toxicology (2016)
  • Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis. Am J Physiol Gastrointest Liver Physiol (2016)
  • RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis. J Am Soc Nephrol (2016)
  • Role of Fibrin(ogen) in Progression of Liver Disease: Guilt by Association?. Semin Thromb Hemost (2016)
  • Role of hemostatic factors in hepatic injury and disease: animal models de-liver. J Thromb Haemost (2016)
  • A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development. Blood (2015)
  • Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice. J Thromb Haemost (2015)
  • Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice. Blood (2015)
  • Circulating microparticle tissue factor activity is increased in patients with cirrhosis. Hepatology (2014)
  • Coagulation in liver toxicity and disease: role of hepatocyte tissue factor. Thromb Res (2014)
  • Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo. Toxicol Sci (2014)
  • H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice. Am J Physiol Gastrointest Liver Physiol (2014)
  • Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice. J Immunol (2014)
  • Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy. J Hepatol (2014)
  • The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury. J Pharmacol Exp Ther (2014)
  • Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in mice. J Pharmacol Exp Ther (2014)
  • Toxicogenomic analysis reveals profibrogenic effects of trichloroethylene in autoimmune-mediated cholangitis in mice. Toxicol Sci (2014)
  • Hepatocyte tissue factor activates the coagulation cascade in mice. Blood (2013)
  • IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis. Am J Pathol (2013)
  • Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding. Free Radic Biol Med (2013)
  • Mechanisms of STAT3 activation in the liver of FXR knockout mice. Am J Physiol Gastrointest Liver Physiol (2013)
  • PAR-1 contributes to the innate immune response during viral infection. J Clin Invest (2013)
  • Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice. Toxicol Appl Pharmacol (2013)
  • Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice. Toxicol Sci (2012)
  • Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury. Am J Pathol (2012)
  • Lipopolysaccharide enhances transforming growth factor β1-induced platelet-derived growth factor-B expression in bile duct epithelial cells. J Gastroenterol Hepatol (2012)
  • Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest (2012)
  • Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease. Am J Pathol (2012)
  • Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes. J Pharmacol Exp Ther (2011)
  • Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis. Am J Pathol (2011)
  • Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet. Am J Pathol (2011)
  • Regulation of transforming growth factor-β1-dependent integrin β6 expression by p38 mitogen-activated protein kinase in bile duct epithelial cells. J Pharmacol Exp Ther (2011)
  • Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury. Toxicol Sci (2011)
  • Steatosis DeLIVERs high-sensitivity C-reactive protein. Arterioscler Thromb Vasc Biol (2011)
  • The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2011)
  • Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice. Toxicol Appl Pharmacol (2011)
  • Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example. Int J Mol Sci (2010)
  • Effect of low-density lipoprotein apheresis on plasma levels of apolipoprotein e4. Am J Cardiol (2010)
  • Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet. Lab Invest (2010)
  • Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies. Toxicol Sci (2010)
  • The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis. Am J Pathol (2010)
  • Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice. Am J Pathol (2010)
  • Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet. J Pharmacol Exp Ther (2009)
  • Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice. Hepatology (2009)
  • Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models. Pharmacol Rev (2009)
  • Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression. Mol Immunol (2009)
  • Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice. Am J Physiol Gastrointest Liver Physiol (2009)
  • Contribution of host-derived tissue factor to tumor neovascularization. Arterioscler Thromb Vasc Biol (2008)
  • Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages. J Immunol (2008)
  • Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice. J Pharmacol Exp Ther (2008)
  • TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages. Mol Immunol (2008)
  • A novel class of antioxidants inhibit LPS induction of tissue factor by selective inhibition of the activation of ASK1 and MAP kinases. Arterioscler Thromb Vasc Biol (2007)
  • COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. J Exp Med (2007)
  • Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine. J Pharmacol Exp Ther (2007)
  • Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. Hepatology (2007)
  • The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury. Toxicol Sci (2007)
  • The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression. Thromb Res (2007)
  • Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine. J Pharmacol Exp Ther (2006)
  • Genetic susceptibility to thrombosis. Curr Atheroscler Rep (2006)
  • Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide. Toxicol Appl Pharmacol (2006)
  • Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1. Gastroenterology (2006)
  • Metformin prevents endotoxin-induced liver injury after partial hepatectomy. J Pharmacol Exp Ther (2006)
  • Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils. J Pharmacol Exp Ther (2006)
  • Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation. J Pharmacol Exp Ther (2006)
  • Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans. Cancer Res (2006)
  • Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine. Toxicol Sci (2006)
  • Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine. J Pharmacol Exp Ther (2005)
  • Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor. Chem Biol Interact (2004)
  • Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity. Toxicol Lett (2004)
  • Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine. Toxicol Sci (2004)
  • Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats. Hepatology (2004)
  • Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: involvement of endothelium and the coagulation system. Toxicol Sci (2003)
  • Inflammation and drug idiosyncrasy--is there a connection?. J Pharmacol Exp Ther (2003)
  • Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats. J Pharmacol Exp Ther (2003)
  • Antigen-presenting cell function during Plasmodium yoelii infection. Infect Immun (2002)
  • Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose analysis for markers of liver injury. Toxicol Sci (2002)

Employment

  • ZZ1, ZZ2Michigan State University ZZ3East Lansing ZZ$https://ror.org/05hs6h993 ()